Rolipram
Rolipram is a selective cAMP-specific PDE4 inhibitor that elevates intracellular cAMP by blocking its hydrolysis, modulating PKA/EPAC signalling. In oncology research, PDE4 inhibition has anti-inflammatory and pro-apoptotic effects in multiple myeloma and CLL, and synergises with HDAC inhibitors. Used in preclinical studies to model cAMP pathway biology and investigate combination strategies with checkpoint inhibitors.
Description
Scientific Overview: Rolipram is a selective cAMP-specific PDE4 inhibitor that elevates intracellular cAMP by blocking its hydrolysis, modulating PKA/EPAC signalling. In oncology research, PDE4 inhibition has anti-inflammatory and pro-apoptotic effects in multiple myeloma and CLL, and synergises with HDAC inhibitors. Used in preclinical studies to model cAMP pathway biology and investigate combination strategies with checkpoint inhibitors.
Mechanism of Action: PDE4 (Phosphodiesterase 4) Inhibitor
Purity: ≥99% | Molecular Formula: C16H21NO3
For Research Use Only. Not intended for diagnostic, therapeutic, or clinical applications.
Additional information
| Effect | PDE4 (Phosphodiesterase 4) Inhibitor |
|---|---|
| Purity | ≥99% |
| Molecular Formula | C16H21NO3 |
| CAS Number | 61413-54-5 |
