Plicamycin
Plicamycin (mithramycin A) is a glycosylated aureolic acid antibiotic that intercalates into GC-rich DNA regions and displaces SP1/SP3 transcription factors, suppressing expression of SP1-driven oncogenes including c-MYC, MDM2, and telomerase. It is a potent calcium-lowering agent used clinically for hypercalcaemia of malignancy; renewed preclinical interest in Ewing sarcoma and NF1-associated tumours.
Description
Scientific Overview: Plicamycin (mithramycin A) is a glycosylated aureolic acid antibiotic that intercalates into GC-rich DNA regions and displaces SP1/SP3 transcription factors, suppressing expression of SP1-driven oncogenes including c-MYC, MDM2, and telomerase. It is a potent calcium-lowering agent used clinically for hypercalcaemia of malignancy; renewed preclinical interest in Ewing sarcoma and NF1-associated tumours.
Mechanism of Action: RNA Polymerase Inhibitor / GC-rich DNA Binder / SP1 Inhibitor
Purity: ≥99% | Molecular Formula: C52H76O24
For Research Use Only. Not intended for diagnostic, therapeutic, or clinical applications.
Additional information
| Effect | RNA Polymerase Inhibitor / GC-rich DNA Binder / SP1 Inhibitor |
|---|---|
| Purity | ≥99% |
| Molecular Formula | C52H76O24 |
| CAS Number | 18378-89-7 |
