Pictilisib
Pictilisib (GDC-0941) is a potent, selective pan-PI3K inhibitor targeting all Class I isoforms (p110alpha/beta/delta/gamma) with low nanomolar potency. It competitively inhibits ATP binding in the PI3K catalytic domain and suppresses downstream AKT and S6K phosphorylation. Used extensively as a research tool to study PI3K pathway biology; clinical trials reinforced need for combination strategies.
Description
Scientific Overview: Pictilisib (GDC-0941) is a potent, selective pan-PI3K inhibitor targeting all Class I isoforms (p110alpha/beta/delta/gamma) with low nanomolar potency. It competitively inhibits ATP binding in the PI3K catalytic domain and suppresses downstream AKT and S6K phosphorylation. Used extensively as a research tool to study PI3K pathway biology; clinical trials reinforced need for combination strategies.
Mechanism of Action: Pan-PI3K Inhibitor (Class I)
Purity: ≥99% | Molecular Formula: C23H26N6O3S
For Research Use Only. Not intended for diagnostic, therapeutic, or clinical applications.
