Eribulin
Eribulin is a synthetic macrocyclic ketone analogue of halichondrin B, a natural product from the marine sponge Halichondria okadai. It binds specifically to the plus ends of microtubules, suppressing dynamic instability without affecting depolymerisation—a distinct mechanism from taxanes. FDA-approved for locally advanced/metastatic breast cancer and liposarcoma.
Description
Scientific Overview: Eribulin is a synthetic macrocyclic ketone analogue of halichondrin B, a natural product from the marine sponge Halichondria okadai. It binds specifically to the plus ends of microtubules, suppressing dynamic instability without affecting depolymerisation—a distinct mechanism from taxanes. FDA-approved for locally advanced/metastatic breast cancer and liposarcoma.
Mechanism of Action: Microtubule Dynamics Inhibitor (halichondrin analogue)
Purity: ≥99% | Molecular Formula: C40H59NO11
For Research Use Only. Not intended for diagnostic, therapeutic, or clinical applications.
Additional information
| Effect | Microtubule Dynamics Inhibitor (halichondrin analogue) |
|---|---|
| Purity | ≥99% |
| Molecular Formula | C40H59NO11 |
| CAS Number | 253128-41-5 |
